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However, it has been more difficult to automate the counting of specific cell types with complex morphologies in mixed cell cultures. The ability to diminish apoptosis may contribute to maintaining healthy tissues.Īutomated image-based and biochemical assays have greatly increased throughput for quantifying cell numbers in in vitro studies.
Importantly, both cerium oxide and platinum nanoparticles reduce oxidant-mediated apoptosis in target cells as judged by the activation of caspase 3. Furthermore, cerium oxide and platinum nanoparticles demonstrated superoxide dismutase catalytic activity, but did not promote hemolytic or cytolytic pathways in living cells. Using surface plasmon-enhanced microscopy, we find that these nanoparticles associate with cells. Cerium oxide and platinum nanoparticles were found to be 16 ± 2.4 and 1.9 ± 0.2 nm in diameter, respectively. In the present study, we directly compare these two classes of catalytic nanoparticles. Cerium oxide and platinum nanoparticles represent two potentially therapeutic nanoparticles that de-toxify ROS. Several diseases, including many blinding eye diseases, are promoted by excessive oxidant stress due to reactive oxygen species (ROS). HIGH-THROUGHPUT, HIGH CONTENT SCREENINGĬatalytic nanoparticles represent a potential clinical approach to replace or correct aberrant enzymatic activities in patients.PROTEIN DETECTION, QUANTITATION, ANALYSIS.NUCLEIC ACID (DNA/RNA) DETECTION & ANALYSIS.
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